Dr Hughes co-authored the ANSI approved HL7 V3 message to transmit family history data and is the co-creator of CRA Health (Acquired by Volpara), which calculates cancer risk for over 5,000,000 patients each year. He is the Co-Creator of Ask2Me.Org which calculates risk specifically for patients with mutations in cancer susceptibility genes (over 2000 page-views each months) and HereditaryCancer.AI, which uses Graph database technology to illustrate hereditary cancer genes and their related cancers. While continuing an active clinical practice, Dr Hughes is developing software that simplifies the management of patients with mutations in cancer susceptibility genes.